Selected Project Work

Six representative HEOR / RWE deliverables — oncology, cardiology, hematology, evidence synthesis, and payer modeling.

Selected Work

Real projects from our portfolio — registries, a neurology trial, payer and policy models, AI tools, dashboards, and evidence synthesis. Client names withheld — methods and outputs shown.

HEOR Deliverable

SAP • TLF • R/SAS output

Featured
RWE · Oncology

Oncology Real-World Registry Study

Statistical analyses for a prospective, multicentre observational registry of patients with advanced solid tumours — patient profiles, disease characteristics, biomarker status, treatment patterns, and clinical outcomes.

RRegistryBiomarkersTLF

What was delivered

  • ✓Molecular-marker subgroup analyses
  • ✓Descriptive + inferential TLFs
  • ✓Treatment-pattern insights

HEOR Deliverable

SAP • TLF • R/SAS output

Featured
Clinical Trial · Neurology

Anti-Integrin Dosing Trial — Multiple Sclerosis

Evaluated an alternative dosing regimen versus standard 4-week dosing: Kaplan-Meier assessment of relapse rates, disability progression, adverse events, and lesion activity.

KM CurvesRCTCROR

What was delivered

  • ✓KM curves per clinical endpoint
  • ✓Dosing-regimen comparison
  • ✓Efficacy + safety readouts

HEOR Deliverable

SAP • TLF • R/SAS output

HEOR · Public Health

Childhood Anemia Microsimulation

Microsimulation model of cereal-food interventions for childhood anemia — long-term health outcomes and economic impact to guide policymakers and healthcare providers.

MicrosimulationCEAPolicyR

What was delivered

  • ✓Long-term outcome simulation
  • ✓Intervention cost-savings estimates
  • ✓Policymaker-ready outputs

HEOR Deliverable

SAP • TLF • R/SAS output

HEOR · Health Policy

Hypothyroidism Screening Markov Model

10-year Markov microsimulation of universal hypothyroidism screening for national health policy — QALYs, costs, disease progression, with SLR-sourced inputs across age and socioeconomic strata.

MarkovSLR InputsQALY10-Year

What was delivered

  • ✓10-year clinical + economic projections
  • ✓QoL + CVD-prevention impact
  • ✓Age/SES-stratified outputs

HEOR Deliverable

SAP • TLF • R/SAS output

RWE · Cardiology

ASCVD Lipid Outcomes Study

Real-world study of lipid target attainment and treatment intensification in high-risk ASCVD patients — guideline LDL-C targets, longitudinal lipid reduction, and time-to-treatment-escalation.

RLongitudinalLDL-CSurvival

What was delivered

  • ✓LDL-C target-attainment analysis
  • ✓Lipid-reduction quantification
  • ✓Treatment-escalation timelines

HEOR Deliverable

SAP • TLF • R/SAS output

RWE · Diabetes

Cardiometabolic Risk Prediction — Diabetes

Early cardiovascular-risk detection among adults with diabetes: prevalence of risk markers plus multivariable logistic models identifying independent predictors of elevated risk.

LogisticRRisk PredictionCross-Sectional

What was delivered

  • ✓Independent risk predictors identified
  • ✓Diabetes-subgroup comparisons
  • ✓Screening-ready risk profiles

HEOR Deliverable

SAP • TLF • R/SAS output

PRO · Hematology

HRQoL Research — Hematological Disorders

International quality-of-life study: patient-reported outcomes across multiple QoL domains, with clinical and demographic drivers of well-being and treatment satisfaction.

PRORegressionQoLPublication-Ready

What was delivered

  • ✓Multi-domain QoL evaluation
  • ✓Driver analysis via regression
  • ✓Publication-ready tables

HEOR Deliverable

SAP • TLF • R/SAS output

Evidence Synthesis

Systematic Review + Meta-Analysis

End-to-end evidence synthesis on therapeutic effectiveness and safety — literature screening, data extraction, quality assessment, analysis, and patient-centred (QoL) interpretation.

SLRMeta-AnalysisPRISMAQoL

What was delivered

  • ✓Screened + quality-assessed evidence base
  • ✓Pooled effectiveness + safety estimates
  • ✓Patient-centred conclusions

HEOR Deliverable

SAP • TLF • R/SAS output

Featured
RWE · Longitudinal

Chronic Disease Registry — Longitudinal Outcomes

Longitudinal registry of chronic-disease complications: treatment-pattern utilization, clinical/lab trajectories, and quality-of-life outcomes via mixed models and repeated-measures analysis.

Mixed ModelsLongitudinalPROR

What was delivered

  • ✓Treatment-effectiveness evidence
  • ✓Lab-trajectory modeling
  • ✓Safety + QoL assessment

HEOR Deliverable

SAP • TLF • R/SAS output

Featured
AI Tool · Clinical Data

Clinical Data Platform — CRF & SLR Pipeline

AI-powered platform automating clinical trial documentation: upload a protocol and get a complete CRF package (22+ forms), CDASH metadata, traceability matrix, QC report, and SLR protocol in minutes.

PythonOpenRouter AICDASHAutomation

What was delivered

  • ✓Study startup cut from weeks to minutes
  • ✓CDASH v2.1 compliant outputs
  • ✓10-point automated QC checks

HEOR Deliverable

SAP • TLF • R/SAS output

AI Tool · Screening

Automated Eligibility Criteria Screener

AI tool that reads patient EHR summaries and checks them against protocol inclusion/exclusion criteria using LLMs — instant screening decisions with reasoning.

PythonLLMNLPStreamlit

What was delivered

  • ✓70% less manual review time
  • ✓Instant decisions with reasoning
  • ✓Protocol-criteria automation

HEOR Deliverable

SAP • TLF • R/SAS output

AI Tool · SAP

Automated SAP Generator

Takes a clinical protocol as input and generates a complete Statistical Analysis Plan: analysis populations, endpoints, statistical methods, and table shells.

PythonLLMNLPAutomation

What was delivered

  • ✓SAP drafts in minutes, not days
  • ✓Populations, endpoints + methods
  • ✓Table shells included

HEOR Deliverable

SAP • TLF • R/SAS output

Dashboard · Survival

R Shiny — Survival Analysis Explorer

Interactive web application for Kaplan-Meier estimation, Cox regression, and competing risk analysis. Upload CSV data and get publication-ready survival plots and statistical summaries.

R ShinyKM CurvesCoxInteractive

What was delivered

  • ✓KM, Cox + competing-risk analysis
  • ✓CSV upload workflow
  • ✓Publication-ready plots

HEOR Deliverable

SAP • TLF • R/SAS output

Dashboard · HEOR

R Shiny — HEOR Model Dashboard

Interactive Markov model dashboard for cost-effectiveness analysis. Configure model parameters, run sensitivity analyses, and generate ICER results in real time.

R ShinyMarkovCEAICER

What was delivered

  • ✓Real-time ICER results
  • ✓Sensitivity analyses built in
  • ✓Parameter-scenario testing

Need the full SAP/TLF or model for your molecule? We scope fixed-price HEOR support.

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